Cloning of a Serotonin Transporter Affected by Antidepressants
- 25 October 1991
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 254 (5031) , 579-580
- https://doi.org/10.1126/science.1948036
Abstract
A complementary DNA clone for a serotonin (5HT) transporter has been isolated from rat basophilic leukemia cells. The complementary DNA sequence predicts a 653-amino acid protein with 12 to 13 putative transmembrane domains. The 5HT transporter has significant homology to the gamma-aminobutyric acid, dopamine, and norepinephrine transporters. Uptake by CV-1 cells expressing the transporter complementary DNA resembles 5HT uptake by platelets and brain synaptosomes; it is sensitive to antidepressants, amphetamine derivatives, and cocaine.Keywords
This publication has 27 references indexed in Scilit:
- Expression cloning of a cocaine-and antidepressant-sensitive human noradrenaline transporterNature, 1991
- Cloning of the human brain GABA transporterFEBS Letters, 1990
- Leucine-zipper motif updateNature, 1989
- Drugs interacting with 5-HT systems show promise for treatment of eating disordersTrends in Pharmacological Sciences, 1989
- The 5-hydroxytryptamine system of blood platelets: physiology and pathophysiologyInternational Journal of Cardiology, 1987
- Patterns of Amino Acids near Signal‐Sequence Cleavage SitesEuropean Journal of Biochemistry, 1983
- A simple method for displaying the hydropathic character of a proteinJournal of Molecular Biology, 1982
- Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionBiochemical Pharmacology, 1973
- Uptake of Serotonin in Blood Platelets in vitro. I: The Effects of ChlorideActa Physiologica Scandinavica, 1971
- 5-hydroxytryptamine uptake by rat brain in vitroLife Sciences, 1967