THE QUESTION OF THE DESTRUCTION OF 17,21-HYDROXYCORTICOSTEROIDS BY PHOSGENE
- 1 March 1955
- journal article
- letter
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 15 (3) , 377-379
- https://doi.org/10.1210/jcem-15-3-377
Abstract
Phosgene, a product of the oxidation of CHCl3, was shown to have no destructive effects on CHCl3 solutions of steroids giving the Porter-Silber reaction or on purified urinary CHCl3 extracts. Re-distilled USP or reagents grades of CHCl3 could be stored 3 weeks without harmful effects on these steroids. The effects of other oxidation products of CHCl3 on steroids is being investigated.Keywords
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