Stereospecific inversion of (R)-(−)-benoxaprofen in rat and man

1 July 1980

journal article
research article
Published by Springer Nature in European Journal of Drug Metabolism and Pharmacokinetics

Vol. 5 (3) , 169-172
https://doi.org/10.1007/bf03189461

Abstract

Summar (R)-(−)-benoxaprofen is stereospecifically inverted to the (S)-( + )-enantiomer by rats and humans. The rate of inversion is much faster in rats (t1/2ca. 2.5 h) than in humans (t1/2 108 h). Inversion in rats apparently does not occur in the liver, but can be brought about in vitro by an everted intestinal sac preparation, suggesting that the transformation takes place while passing through the gut wall.

Keywords

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