The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme
- 1 January 1997
- journal article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 4 (1) , 32-35
- https://doi.org/10.1038/nsb0197-32
Abstract
Transfection studies with cDNAs encoding hybrids between the highly similar cytochrome P450 enzymes, CYP11B1 (steroid 11 beta-hydroxylase) and CYP11B2 (aldosterone synthase) have identified which amino acids determine the different activities of the enzymes.Keywords
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