Studies on the blood fibrinolytic enzyme system of patients with cutaneous vasculitis

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Abstract
The fibrinolytic enzyme system in 32 patients suffering from cutaneous vasculitis was investigated. In 5 of 7 patients with Behcet''s disease and in 5 of 13 patients with erythema nodosum, a significant elongation of euglobulin lysis time was observed. In 2 patients with allergic vasculitis, a significant shortening of euglobulin lysis time was noticed. Factors responsible for the change of euglobulin lysis time were sought. The significant elongation of euglobulin lysis time in patients with erythema nodosum was based on an increase of fibrinogen content in the euglobulin fraction. The elongation of euglobulin lysis time in patients with Behcet''s disease might be due to an increase of antiactivators in the patients'' plasma. The status of this antiactivator was investigated and the possibility that the increased antiactivator might consist of at least 2 types of antiactivators, one of which is considered to be an .alpha.2-plasmin inhibitor, is proposed.