Antagonistic Relationship Between Oral Organisms

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Abstract
Since the oral flora changes to a predominance of Gram-negative organisms when large doses of penicillin are administered orally, it was desirable to know whether any of these organisms are antagonistic to the growth of Lactobacillus acidophilus. By means of broth cultures in wells separated from seeded agar plates by celloidin cups, or by agar plugs surrounded by poured inoculated agar, L. acidophilus has been found to inhibit the growth of several organisms, mostly of the families Enterobacteriaceae and Micro-coccaceae. Of the family Enterobacteriaceae which were inhibited, Aerobacter aerogenes and Esherichia coli occur most frequently in the oral flora after penicillin. Filtrates of A. aerogenes and E. coli inhibit the growth of L. acidophilus. Only one organism, Sarcina lutea, was inhibited by growing A. aerogenes. The degree of inhibition observed was influenced by the production in the substrate of a pH more favorable to one organism than to another.

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