THE EFFECTS OF 3 DIFFERENT HEPARIN REGIMES ON HEPARIN CONCENTRATIONS IN PLASMA AND FIBRIN FORMATION IN DIALYZERS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 15  (3) , 135-142
Abstract
Anticoagulation effects were studied during a 4 h hemodialysis in 6 patients using 3 different heparin regimens: i.v. loading dose only; priming of the dialyzer and continuous infusion of heparin for 2 h and, i.v. loading dose and continuous infusion of heparin based on anticoagulation kinetics. In all regimens the difference of fibrinopeptide A (.DELTA.FPA) between the blood inlet and outlet of the dialyzers increased at the end of the dialyses, indicating increased fibrin formation. There was a good correlation between .DELTA.FPA and the fibrin deposition on the membranes measured with 125I-fibrinogen. .DELTA.FPA increased when heparin concentration in plasma was < 0.5 IU/ml. The anticoagulation kinetic regimen offered no advantage over the single loading dose regimen with regard to the formation and deposition of fibrin in the dialyzers.