ENDOMETRIAL CANCER ASSOCIATED WITH FEMINIZING OVARIAN TUMOR AND POLYCYSTIC OVARIAN DISEASE

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 49  (6) , 654-658
Abstract
Feminizing ovarian tumors and polycystic ovarian disease may cause endometrial cancer by abnormal, unopposed endogenous estrogenic stimulation. The clinical course of 72 endometrial cancer patients with a concomitant feminizing ovarian tumor or polycystic ovarian disease was reviewed and tumor characteristics and treatment results were compared with those exhibited by 523 pateitnts treated for endometrial cancer alone. With functioning ovarian tumor and polycystic ovaries, the cancer tended to be more often low-grade, low-stage and superficial than endometrial cancer alone. The high 5- and 10-yr survival rates observed in these functioning ovarian tumor-polycystic ovary pateints support the conclusion that endometrial carcinoma with a coexistent endogenous estrogenic stimulus has a more favorable prognosis (P < 0.01) than endometrial carcinoma alone.