SUPPRESSION OF PARATHYROID SECRETION AFTER ADMINISTRATION OF WR‐2721 IN A PATIENT WITH PARATHYROID CARCINOMA

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Abstract
SUMMARY: WR‐2721 is an organic thiophosphate, known as a radioprotective agent, which also inhibits parathyroid hormone (PTH) secretion and reduces the plasma calcium level in euparathyroid animals and human subjects. In this study we present evidence that WR‐2721 is also able to reduce an abnormal PTH secretion in a case of parathyroid carcinoma. The intravenous infusion of a single dose (750 mg/m2) of WR‐2721 was followed within 3 h by a reduction in the plasma concentration of PTH by 60%, and of Ca by about 0·45 mmol/l. These changes were associated with a diminution in urinary cAMP excretion. Based on this observation it appears that WR‐2721 merits further investigation as a possible agent for the medical treatment of hyperparathyroidism.