Heritable Fragile Site on Chromosome 16: Probable Localization of Haptoglobin Locus in Man

2 October 1970

journal article
other
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 170 (3953) , 85-87
https://doi.org/10.1126/science.170.3953.85

Abstract

We have found recurrent chromosome breaks at a site (the "fragile site") on the long arm of chromosome 16. This site segregates in simple Mendelian dominant fashion in a large family. The distal portion of the chromosome sometimes shows selective endoreduplication. Preliminary linkage results reveal only 3 recombinants in 33 opportunities for recombination between the fragile site and the alpha locus of haptoglobin, an indication that the α-Hp gene is located near this region on chromosome 16.

Keywords

This publication has 6 references indexed in Scilit:

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