Macrolactams Two novel homologous series of compounds produced by Actinomadura sp. SCC 1778.
- 1 January 1992
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 45 (5) , 633-638
- https://doi.org/10.7164/antibiotics.45.633
Abstract
Eight antifungal compounds were identified from the fermentation of Actinomadura sp. SCC 1778. This culture produces four homologous compounds (C22H42N2O5-C25H48N2O5) containing the sugar, mycosamine, and four homologous compounds (C22H42N2O5-C25H48N2O5) containing the sugar, 3, 6-dideoxy-3-amino-L-talopyranose. Five of the compounds identified were novel macrolactams. All these compounds exhibit antifungal activity against Candida spp. with geometric mean MICs ranging from approximately 1.0 μg/ml for the higher homologs to 30 μg/ml for the lower homologs.Keywords
This publication has 0 references indexed in Scilit: