AMINOTETRALIN ANALOGS OF METHOXAMINE AS POTENTIAL HYPERTENSIVE AGENTS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 19  (1) , 37-55
Abstract
Cardiovascular effects of methoxamine and some aminotetralin derivatives (5,8-ADT[5,8-dimethoxy-2-aminotetralin hydrochloride], DR-31 [N-methyl-5,8-dimethoxy-2-aminotetralin hydrochloride] and DR-71 [N,N-dimethoxy-2-aminotetralin hydrochloride]) were studied after systemic i.v. or intraarterial injection into different perfused vascular beds in anesthetized dogs. I.v. administration of the compounds produced dose-related prolonged increases in blood pressure, which were antagonized by phentolamine. After intra-arterial injection into the perfused hindlimb, mesenteric artery or the saphenous vein, all compounds produced dose-dependent increases in perfusion pressure indicative of vasoconstriction. Phentolamine antagonized these effects. Desipramine significantly reduced the vasoconstricting actions of intra-arterially injected tyramine in the hindlimb, but did not alter the responses induced by methoxamine and aminotetralin derivatives. These compounds apparently elicit peripheral vasoconstriction in the dog through a direct action on the .alpha.-adrenergic receptors.