Effects of septal area and cingulate cortex lesions on opiate addiction behavior in rats.

1 January 1971

journal article
Published by American Psychological Association (APA) in Journal of Comparative and Physiological Psychology

Vol. 75 (2) , 277-285
https://doi.org/10.1037/h0030810

Abstract

60 Sprague-Dawley albino rats were given bilateral lesions in the septal area or cingulate cortex and then subjected to a regimen previously shown to produce drug addiction in animals. The addiction was indexed by a learned preference for a bitter morphine HC1 solution. Ss were tested for relapse following a 2-wk withdrawal of drugs. Bilateral anterior cingulate cortex lesions resulted in a decrement in both the acquisition and retention (relapse) of drug-oriented behavior. Bilateral septal lesions produced no changes in addiction behavior. Further tests with 20 Ss indicated that the results apparently were not due to any effects of cingulate cortex lesions on reactions to the bitter taste of morphine HC1. (16 ref.) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

Keywords

This publication has 0 references indexed in Scilit: