ORAL GLUCOSE INHIBITS GROWTH HORMONE SECRETION INDUCED BY HUMAN PANCREATIC GROWTH HORMONE RELEASING FACTOR 1–44 IN NORMAL MAN

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Abstract
SUMMARY: The interaction between the inhibitory effect on growth hormone secretion of a 75 g oral glucose load and the stimulatory effect of human pancreatic growth hormone releasing factor 1–44 (hpGRF 1–44, 10 μg i.v.) has been studied in six normal subjects. hpGRF 1–44 alone induced a rise in growth hormone concentrations (maximum mean ± SEM, 16–5 ± 1.7 mU/1 15 min after injection) while growth hormone levels were suppressed by oral glucose alone (& < 1 ‐5 mU/1 from 45 to 135 min after glucose ingestion). When hpGRF 1–44 was injected 60 min after oral glucose, the growth hormone response was attenuated (maximum, 6.7±1.4 mU/1 at 15 min, P<005). Increments of blood glucose within the physiological range diminish the growth hormone response to hpGRF 1‐44 in normal man.