Avascular Necrosis and Erythrocytosis in Sickle-Cell Trait
- 21 February 1974
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 290 (8) , 442-444
- https://doi.org/10.1056/nejm197402212900807
Abstract
THE association of bilateral avascular (aseptic) necrosis of the femoral heads with homozygous hemoglobin S (sickle-cell anemia) and probably more often with hemoglobinopathies SC and S-thalassemia has long been appreciate. 1 2 3 Since 1962, four cases of hemoglobin AS (sickle-cell trait) presumably complicated by this orthopedic problem have been report4 5 6 The white patient described below had hemoglobin AS, bilateral avascular necrosis of the femoral heads, and an unexplained absolute erythrocytosis.MethodsRoutine clinical laboratory and hematologic data obtained by standard technics,7 and total blood volume and red-cell mass were measured by conventional methods using radioiodinated human serum albumin and 51Cr-tagged red cells. . . .Keywords
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