Activation of BKCa channels in acutely dissociated neurones from the rat ventromedial hypothalamus by NS 1619
Open Access
- 1 November 1994
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 113 (3) , 659-661
- https://doi.org/10.1111/j.1476-5381.1994.tb17041.x
Abstract
NS 1619 activates the large-conductance Ca2+-dependent K+ channel (BKCa) in membrane patches isolated from rat ventromedial hypothalamic neurones. The activation is concentration dependent, with a maximal effect at less than 30 μm, reversible and can be inhibited by application of iberiotoxin to the extracellular membrane. NS 1619 does not activate ATP-K+ channels present in the same neurones.Keywords
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