The dependence of HNO2 mutagenesis in phage T4 on ligase and the lack of dependence of 2AP mutagenesis on repair functions
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 148 (2) , 213-220
- https://doi.org/10.1007/bf00268387
Abstract
A temperature sensitive ligase allele of phage T4 reduced or eliminated HNO2 induced reversion of am mutants. Since at the temperatures used, the ligase mutant is defective in the repair of some types of lethal lesions (i.e., UV, MMS and EMS induced lesions) these results indicate that HNO2 mutagenesis may occur through a ligase dependent repair pathway. In contrast, 2AP induced mutation was not inhibited by mutants defective in the gene 30 ligase or in genes 32, 39, 41, 44, 45, 46, 47, 49, 52, 56, 58–61 and v. This indicates that 2AP mutagenesis probably does not depend on a repair pathway in phage T4.This publication has 42 references indexed in Scilit:
- Effects of p-fluorophenylalanine on the induction of mutations in bacteriophage T4Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1975
- Bromouracil mutagenesis: mispairing or misrepair?Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1974
- Recovery of phage T4 from nitrous acid damageMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1974
- On the mechanism of bromouracil-induced mutagenesisMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1973
- Stimulation of mutation in phage T4 by lesions in gene 32 and by thymidine imbalanceMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1972
- Enhanced recovery of rII mutations in the absence of selection in a ligase-negative mutant of bacteriophage T4Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1972
- Effects of the rec and exr mutations of Escherichia coli on UV reactivation of bacteriophage lambda damaged by different agentsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1972
- The base specificity of mutation induced by nitrous acid in phage T2Biochemical and Biophysical Research Communications, 1960
- The reaction of nitrous acid with deoxyribonucleic acidBiochemical and Biophysical Research Communications, 1960
- The specific mutagenic effect of base analogues on Phage T4Journal of Molecular Biology, 1959