Pineal N -Acetyltransferase Is Inactivated by Disulfide-Containing Peptides: Insulin Is the Most Potent
- 31 July 1981
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 213 (4507) , 571-573
- https://doi.org/10.1126/science.7017937
Abstract
Pineal N-acetyltransferase can be inactivated in broken cell preparations by cystamine through a mechanism of thiol-disulfide exchange. Some, but not all, disulfide-containing peptides can inactivate this enzyme; the most potent inactivator is insulin. These findings suggest that a disulfide-containing peptide with high reactivity toward N-acetyltransferase may participate in the intracellular regulation of this enzyme.Keywords
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