Derivative Spectrophotometric Determination of Some Corticosteroids in Combinations with Other Drugs
Open Access
- 1 July 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of AOAC INTERNATIONAL
- Vol. 69 (4) , 614-618
- https://doi.org/10.1093/jaoac/69.4.614
Abstract
Three 2-component mixtures, namely, dexamefhazone-chlorpheniramine maleate, prednisolone-chlorpheniramine maleate, and prednisolone-salicylic acid, have been assayed using their first (D1,) and second (D2) derivative spectra in methanol, delta absorption (ΔA), and second derivative of Δ A (Δ D2) spectra in methanol-methanolic HC1. In the first 2 mixtures, chlorpheniramine maleate was determined by measuring its Δ D2 value at 278 nm, while dexamethazone and prednisolone were analyzed by measuring their D1 values at 248 nm. Prednisolone and salicylic acid were analyzed in combination by using their respective D2 spectral responses at 272 and 314 nm. The results obtained are reasonably reproducible with a relative standard deviation <2%. The method has been successfully applied to the analysis of these drugs in their pharmaceutical formulations.This publication has 0 references indexed in Scilit: