Further evidence for a cAMP dependent regulation of tyrosine-3-monoxygenase induction in adrenal medulla
- 1 January 1975
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 287 (2) , 213-217
- https://doi.org/10.1007/bf00510452
Abstract
Unilateral adrenal denervation caused a gradual decrease of adenylate cyclase activity in rat adrenal medulla. The extent of the increase in adrenal medullary 3′,5′-cyclic adenosine monophosphate (cAMP) content elicited by injections of carbamylcholine declined gradually following adrenal denervation. Three or nine days after denervation carbamylcholine caused rise of cAMP and a delayed increase of tyrosine-3-mono-oxygenase (TH) activity of similar magnitude in intact and denervated adrenal medullae. However, after an interval of 15 days or longer following denervation the increase in TH activity elicited by carbamylcholine was greatly reduced. These results support previous proposals that cAMP is involved as a second messenger in the trans-synaptic induction of TH.Keywords
This publication has 11 references indexed in Scilit:
- Protein kinase activation as an early event in the trans-synaptic induction of tyrosine 3-monooxygenase in adrenal medulla.Proceedings of the National Academy of Sciences, 1975
- Do cyclic nucleotides promote the trans-synaptic induction of tyrosine hydroxylase?Life Sciences, 1974
- Involvement of Adenosine 3′,5′-Monophosphate in the Activation of Tyrosine Hydroxylase Elicited by DrugsScience, 1973
- TRANSSYNAPTIC REGULATION OF TYROSINE HYDROXYLASE IN ADRENAL MEDULLA: POSSIBLE ROLE OF CYCLIC NUCLEOTIDESPublished by Elsevier ,1973
- MONOAMINE OXIDASE: AN APPROXIMATION OF TURNOVER RATESJournal of Neurochemistry, 1971
- Solubilization and Partial Purification of Tyrosine Hydroxylase from Bovine Adrenal MedullaJournal of Biological Chemistry, 1971
- Effect of stimulation on the levels of tyrosine hydroxylase, dopamine beta-hydroxylase, and catecholamines in intact and denervated rat adrenal glands.1971
- Increase in tyrosine hydroxylase activity after reserpine administration.1969
- A SIMPLIFIED RADIOCHEMICAL ASSAY FOR CHOLINE ACETYLTRANSFERASEJournal of Neurochemistry, 1967
- Mechanism of Nicotinic Action at the Adrenal Medulla: Calcium as a Link in Stimulus-secretion CouplingNature, 1961