Increased frequency of the MZ phenotype of alpha-1-protease inhibitor in juvenile chronic polyarthritis.
Open Access
- 1 December 1977
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 60 (6) , 1442-1444
- https://doi.org/10.1172/jci108906
Abstract
Pi phenotypes of alpha-1-protease inhibitor were determined by isoelectric focusing and print immunofixation in 96 English children suffering from juvenile chronic polyarthritis. A significantly increased frequency of the MZ phenotype (10.41%) was found in comparison with a geographically matched control population (1.6%). The results of this study suggest that the possession of a Z-deficient allele of alpha-1-protease inhibitor could be a predisposing, aggravating, or perpetuating factor in the articular damage occurring in juvenile chronic polyarthritis.This publication has 15 references indexed in Scilit:
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