ANTIHYPERTENSIVE EFFECTS OF β-BLOCKERS IN HYPERTENSIVE RATS
Open Access
- 1 January 1975
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 25 (1) , 82-84
- https://doi.org/10.1254/jjp.25.82
Abstract
Wister-Imamichi rats of either sex, weighing between 180 and 350 g were used to induce renal and dihydroxycorticosterone acetate [DOCA]-hypertension. SHR [spontaneously hypertensive rats] were also studied. DOCA (50 mg/kg) was injected s.c. once a week, as 25 mg/ml suspension in 4% gum arabic after unilateral nephrectomy (left kidney). Instead of tap water 1% NaCl was given as drinking water. Renal hypertension was produced, by placing a clamp made from silver ribbon around the left renal artery (slit width, 0.2 mm), without contralateral nephrectomy. Administration of .beta.-blockers was started 2 days after operation in these 2 types of experiments. Neither pindolol nor propranolol produced antihypertensive effects.This publication has 3 references indexed in Scilit:
- ANTIHYPERTENSIVE EFFECT OF L-DOPA AND Ro 4-4602 IN THE RATThe Japanese Journal of Pharmacology, 1973
- The Effects of “Immunosympathectomy” on Blood Pressure and Vascular “Reactivity” in Normal and Spontaneously Hypertensive RatsActa Physiologica Scandinavica, 1972