Changes of Histone Hi Subtypes With Aging in Strains of Mice That Possess Different Immunological Characteristics
- 1 November 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Gerontology
- Vol. 40 (6) , 695-699
- https://doi.org/10.1093/geronj/40.6.695
Abstract
Relative proportions of histone H1 proteins were determined for brain, heart, liver, and spleen for five strains of mice as a function of age. The strains examined were SJL/J AND MRL/MPJ-LPR/LPR which develop early resistance to tolerance and A/J, C57Bl/6J and MRL/MPJ-+ /+ which do not. Heart, brain, and liver of most of these strains displayed significant relative increases in histone H1° and coordinate decreases in H1I or HII with age. In contrast, spleen cells, which are highly proliferative, contained little or no histone H1°. Only spleen cells from a mouse strain with a predisposition to lupus erythematosus, MRL/ MPJ-LPR/LPR, displayed any significant H1 changesKeywords
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