Human Immunodeficiency Virus Type 1–Infected Persons with Residual Disease and Virus Reservoirs on Suppressive Highly Active Antiretroviral Therapy Can Be Stratified into Relevant Virologic and Immunologic Subgroups
Open Access
- 1 June 2001
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 183 (11) , 1682-1687
- https://doi.org/10.1086/320715
Abstract
A significant percentage of human immunodeficiency virus type 1 (HIV-1)–infected persons treated with highly active antiretroviral therapy (HAART) will develop plasma HIV-1–specific virion RNA levels + T lymphocytes. Detection and quantitation of 2-LTR circular DNA correlated strongly with viral outgrowth patterns and inversely with CD4+ T lymphocyte counts. Relevant subgroups of HIV-1–infected subjects on suppressive HAART with residual viral disease and reservoirs can now be stratifiedKeywords
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