MITOCHONDRIAL POPULATION OF MAMMALIAN CELLS III. NUMBER OF MITOCHONDRIA PER AVERAGE CELL OF RAT LIVER TUMOR INDUCED BY 4-DIMETHYLAMINOAZOBENZENE. SIGNIFICANCE IN THE COMPARATIVE STUDY OF THE MITOCHONDRIAL FRACTION PROPERTIES OF NORMAL TISSUES AND TUMORS
- 1 April 1953
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Medical Sciences
- Vol. 31 (2) , 103-108
- https://doi.org/10.1139/cjms53-011
Abstract
The number of cells per gram of fresh tissue and the number of mitochondria isolated from rat liver and liver tumor homogenates are different. The mitochondrial population, computed from the number of cells and mitochondria per gram of fresh tissue is effectively decreased to about half the normal level in 4-dimethylaminoazobenzene induced hepatic tumor cells. Such a loss of mitochondria in tumor cells might explain some different biochemical properties of the mitochondrial fraction isolated from hepatic tumor cells. Fundamentally a decrease in the mitochondrial population favors a recent hypothesis of carcinogenesis.Keywords
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