Macrosphelide, a Novel Inhibitor of Cell-cell Adhesion Molecule. I. Taxonomy, Fermentation, Isolation and Biological Activities.

1 January 1995

journal article
Published by Japan Antibiotics Research Association in The Journal of Antibiotics

Vol. 48 (12) , 1435-1439
https://doi.org/10.7164/antibiotics.48.1435

Abstract

Potent anti-adherent activity was detected in fermentation extracts of microbial strain FO-5050. Active compounds designated macrosphelide A and B were isolated and the structure was determined to be 16-membered macrolide antibiotics possessing three ester bonds in the ring structure. Macrosphelide A dose-dependently inhibited the adhesion of HL-60 cells to LPS-activated HUVEC monolayer (IC50, 3.5 microM); macrophelide B also inhibited HL-60 adhesion but to a lesser extent (IL50, 36 microM). Macrosphelide A did not show any antimicrobial and cytocidal activities at the concentration of 1000 micrograms/ml and 100 micrograms/ml, respectively.

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