Local Regulation of Effective Blood Flow in Muscle

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Abstract
The techniques of macro- and micro-tissue clearance were used to study reactive hyperemia. Clearance of radioactive iodide from gross injection sites in muscles of rabbits and clearance of micro-injected diffusible dye from the exposed, directly observed spinotrapezius of rats gave evidence for an exact quantitative repayment of effective blood flow debt. In both types of preparation a subnormal clearance followed a thermally induced hyperemia as an apparent compensation. The exact quantitative repayment and compensation support the hypothesis that local effective blood flow is in a steady-state relation to the local concentration in tissue fluid of some agent with vasodilating properties. It is suggested that an extension of this method to studies of vasodilatation induced by drugs or other chemicals might offer an approach to identification of the normal vasodilator, and to physiological proof of its exact nature.