Monoclonal Antibody MACG1 Distinguishes Between Different Molecular Species of the Ganglioside GM3

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Abstract
The present study investigates the chemical structure of a ganglioside, detected by monoclonal antibody (MAb) MacGl, which reacts with intracytoplasmic granules of tumor-infiltrating macrophages. The results obtained by enzymatic hydrolysis and fast-atom bombardment-mass spectrometry reveal that MAb MacGl reacts with a subcomponent of the ganglioside GM3 found in melanoma and bovine brain. MAb MacGl might be a powerful tool to distinguish among GM3 species and could help to define their possibly different biological functions.