Localized Osteomyelitis Due toMycobacterium aviumComplex in Patients with Human Immunodeficiency Virus Receiving Highly Active Antiretroviral Therapy

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Abstract
We describe 3 patients who developed atypical manifestations of Mycobacterium avium complex (MAC) infection µ10 months (range, 3–16 months) after attaining sustained CD4+ T cell counts of µ100 cells/µL while receiving antiretroviral therapy and not receiving MAC prophylaxis. The common features of these cases include the degree of immune reconstitution, the unusual locations of the infections, and the absence of a systemic inflammatory response. The low rate of these unusual MAC infections does not warrant continuation of primary or secondary prophylaxis after presumed immune reconstitution.