Triplet States of Tryptophan, N-Formylkynurenine, and UV-Irradiated Lens Proteins

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Abstract
The decrease in the concentration of the photoexcited triplet state of tryptophan in lens protein with irradiation time is contrasted with the buildup of the concentration of free radical(s) via electron spin resonance (ESR). The results obtained from several species indicate that the rates of the decay of the. ΔMS = ± 2 triplet state signal of tryptophan and the buildup of the free radical signal are nearly identical. This suggests a significant role played by tryptophan in the production of chemically active free radicals which may, in turn, initiate various types of cross-linking between peptides. A second photoexcited triplet state species, which appears to be a N-formylkynurenine derivative, has been found in irradiated rhesus monkey lenses

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