Proximal gastric vagotomy versus long-term maintenance treatment with cimetidine for chronic duodenal ulcer: a prospective randomised trial.
- 8 January 1983
- Vol. 286 (6359) , 98-99
- https://doi.org/10.1136/bmj.286.6359.98
Abstract
Forty-four patients with chronic duodenal ulceration were allocated randomly to either long-term maintenance treatment with cimetidine or proximal gastric vagotomy. All were followed up both clinically and endoscopically for periods of one to four years. The rate of recurrence of ulcer during and after medical treatment was 54% while after surgery it was 10%. One patient developed severe allergic hepatitis while receiving maintenance treatment with cimetidine, and two others had to stop treatment because of possible drug reactions. Patients whose ulceration recurs while they are receiving treatment with cimetidine should be offered the possibility of operation.Keywords
This publication has 8 references indexed in Scilit:
- Bedtime cimetidine maintenance treatment: optimum dose and effect on subsequent natural history of duodenal ulcer.Gut, 1982
- Does treatment with cimetidine extended beyond initial healing of duodenal ulcer reduce the subsequent relapse rate?BMJ, 1982
- Intermittent treatment of duodenal ulcer with cimetidine.BMJ, 1980
- Prophylactic effect of cimetidine in duodenal ulcer disease.BMJ, 1978
- SURVIVAL IN PEPTIC-ULCER1978
- Operative mortality and postoperative morbidity of highly selective vagotomy.BMJ, 1975
- Proximal gastric vagotomy: interim results of a randomized controlled trial.BMJ, 1975
- Peptic ulcer surgery: selection for operation by `earning'Gut, 1969