ADULT HEREDITARY ANTERIOR MEGALOPHTHALMUS SINE GLAUCOMA: A DEFINITE DISEASE ENTITY

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Abstract
DEFINITION AND SYNONYMS The term "anterior megalophthalmus" is used to indicate an enlargement of the anterior segment of the eyeball. The most obvious and striking feature is the enlarged circumference of the cornea, and for this reason the disease has been given various names, such as megalocornea, macrocornea, keratoglobus, keratomegalia, cornea globosa, cornea bulbosa, macrophthalmus, hydrophthalmos congenitus anterior, hydrops cameri anterior, globular pellucid staphyloma, gigantophthalmus and enlarged eyeball. It is my purpose in this paper, however, to show that the pathologic changes that characterize this disease are not limited to the cornea but involve the anterior chamber, iris, lens and zonular fibers. As will be shown, the changes are uniform and constitute a definite disease entity which can be easily differentiated from buphthalmos or hydrophthalmos. HISTORY Von Muralt, in 1869, separated cornea globosa semper pellucida from congenital hydrophthalmos. Horner and Michel, in 1889, differentiated a

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