Effects of Adenosine and its Analogues on Porcine Basilar Arteries: Are Only A2 Receptors Involved?
- 1 February 1988
- journal article
- research article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 8 (1) , 40-45
- https://doi.org/10.1038/jcbfm.1988.6
Abstract
The aim of this study was to test the effect of adenosine and four of its analogues, 5'-( N-ethyl)carboxamidoadenosine (NECA), 2-chloroadenosine (2-CADO), L-phenylisopropyladenosine (L-PIA), and N6-cyclohexyladenosine (CHA), on prostaglandin (PG) F2α-constricted pig basilar arteries, and from their rank order of potency determine the receptor type involved, The order of potency for the relaxation of the PGF2α constriction was NECA > adenosine, 2-CADO > L-PIA > CHA, which is in keeping with the A2 receptor subtype, The study also investigated the effects of a known adenosine antagonist, namely, the xanthine derivative 8-phenyltheophylline, which at concentrations having no intrinsic effect (10−8 and 10−7 M) produced a significant shift to the right only for the NECA dose-response curve.Keywords
This publication has 14 references indexed in Scilit:
- A new class of adenosine receptors in brainBiochemical Pharmacology, 1986
- Cobalt ion enhancement of 2-chloro[3H]adenosine binding to a novel class of adenosine receptors in brain: antagonism by calciumBrain Research, 1985
- Characterization of adenosine receptors in isolated cerebral arteries of catBritish Journal of Pharmacology, 1983
- Direct binding studies of adenosine receptorsTrends in Pharmacological Sciences, 1981
- Adenosine receptor activation in human fibroblasts: nucleoside agonists and antagonistsCanadian Journal of Physiology and Pharmacology, 1980
- Subclasses of external adenosine receptors.Proceedings of the National Academy of Sciences, 1980
- Adenine compounds: cerebrovascular effects in vitro with reference to their possible involvement in migraine.Stroke, 1979
- Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis.Proceedings of the National Academy of Sciences, 1978
- Release of Adenosine from Ischemic BrainCirculation Research, 1974
- The Classification of Adrenoceptors (Adrenergic Receptors). An Evaluation from the Standpoint of Receptor TheoryPublished by Springer Nature ,1972