Demonstration of Anti‐Wrb in a Second Serum Containing Anti‐Ena

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Abstract
Many persons who are of a deletion or null phenotype with regard to a particular blood group system, form a complex specificity antibody or mixture of antibodies when immunized. Recently, it was demonstrated that the En(a-), Wr(a-b-) proposita in a family described by Darnborough has at least, anti-Ena and anti-Wrb in her serum. The same 2 antibodies might be present in the serum of the En(a-), Wr(a-b-) propositus in the family reported by Furuhjelm et al. The data presented in this paper confirms that the serum of the propositus does contain antiEna and anti-Wrb and that the antibodies can be separated by adsorption. Because, at this time, it is not known if En(a-), Wr(a-b-) people lack other common antigens from their red blood cells, the possibility remains that the anti-Ena, separated from the anti-Wrb, might be a mixture of antibodies. Previously reported typings for Ena were probably actually performed with mixtures of at least anti-Ena and anti-Wrb. Anti-Ena, lacking antiWrb, can be made only be adsorption of a serum containing the 2 antibodies onto En(a+), Wr(a+b-) red blood cells, with recovery of the anti-Ena by elution.