Association of Rotavirus and Human Immunodeficiency Virus Infection in Children Hospitalized with Acute Diarrhea, Lusaka, Zambia

1 April 1994

journal article
Published by Oxford University Press (OUP) in The Journal of Infectious Diseases

Vol. 169 (4) , 897-900
https://doi.org/10.1093/infdis/169.4.897

Abstract

In Lusaka, Zambia, rotavirus (RV) and human immunodeficiency virus (HIV) infection commonly coexist; 132 (25%) of 537 consecutively studied infants .05), and infants with both viruses more frequently experienced dehydration (P < .05). HIV-infected children more often exhibited respiratory symptoms on admission to the study (P < .0001) and were more frequently underweight (P < .0001) than were HIV-negative children, independent of RV infection. The mortality rate was highest in HIV-positive infants (P < .05), and coinfection with RV did not increase the risk of fatality. This study demonstrates that while RV and HIV infections commonly coexist in one region of Africa, RV infection is no more common nor is the illness more severe in HIV-positive infants.

Keywords

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