Hydroxyl Radical Scavenging and Producing Activities of Water-Soluble Malonic Acid C60
- 1 January 2000
- journal article
- research article
- Published by Taylor & Francis in Fullerene Science and Technology
- Vol. 8 (1-2) , 113-124
- https://doi.org/10.1080/10641220009351402
Abstract
The effects of several water-soluble malonic acid derivatives of C60 with different addition number (M1∼M4) on hydroxyl radical were studied by ESR method. It was shown that the OH signal produced by the Fenton system could be remarkably reduced by M1 and M2, but could not by M3 and M4. The action of M1 and M2 was dose-dependent, and M1 was found to be more effective than M2. In addition, under irradiation and in the presence of oxygen, M2 could produce hydroxyl radicals. These data indicate that the quenching activity of the malonic acid derivative of C60 was closely related to the integrity of conjugated double bonds, and some C60 derivatives with specific structures might act as the eliminator or producer of hydroxyl radicals under different conditions.Keywords
This publication has 15 references indexed in Scilit:
- Biological applications of fullerenesBioorganic & Medicinal Chemistry, 1996
- Superoxide radical quenching and cytochrome C peroxidase-like activity of C60-dimalonic acid, C62(COOH)4Bioorganic & Medicinal Chemistry Letters, 1996
- Free radical scavenging activity of water-soluble fullerenolsJournal of the Chemical Society, Chemical Communications, 1995
- Regiochemistry of Multiple Additions to the Fullerene Core: Synthesis of a Th-Symmetric Hexakis adduct of C60 with Bis(ethoxycarbonyl)methyleneJournal of the American Chemical Society, 1994
- Fullerene Chemistry in Three Dimensions: Isolation of Seven Regioisomeric Bisadducts and Chiral Trisadducts of C60 and Di(ethoxycarbonyl)methyleneAngewandte Chemie International Edition in English, 1994
- Interest of photochemical methods for induction of lipid peroxidationBiochimie, 1994
- Water-soluble malonic acid derivatives of C60 with a defined three-dimensional structureJournal of the Chemical Society, Chemical Communications, 1994
- The chemistry of fullerenesNature, 1993
- Free radical-lipid interactions and their pathological consequencesProgress in Lipid Research, 1993
- Protein Oxidation and AgingScience, 1992