Prenatal treatment of congenital adrenal hyperplasia: Report of a new case
- 31 December 1989
- journal article
- research article
- Published by Springer Nature in European Journal of Pediatrics
- Vol. 149 (4) , 237-240
- https://doi.org/10.1007/bf02106280
Abstract
A mother at risk for 21-hydroxylase deficiency was treated with oral dexamethasone (0.5 mg 12 hourly) from early pregnancy, in an attempt to prevent in utero virilization in case of a female fetus. Fetal karyotype was 46,XX, and because of a possible intra HLA recombination, treatment was continued to term. The newborn had a modest virilization and hormonal studies confirmed the diagnosis of congenital adrenal hyperplasia (CAH). This observation and review of the literature suggest that efficient prenatal treatment of CAH requires a higher and more frequent dosage of dexamethasone.This publication has 19 references indexed in Scilit:
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