CD Spectroscopic Study of Absolute Conformation and Configuration of Some 4-Hydroxychromans

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Abstract
CD data of the optically active 4-hydroxy (1–5) and 4-acetoxy chromans (6–8) were analyzed by two different approaches. The Snatzke-Antus treatment of chiraly perturbed chromane chromophore revealed M absolute conformation and 4S absolute configuration of the alcohols, i.e. P absolute conformation and 4R absolute configuration of the acetates. The proposed absolute configuration of the optically active alcohols was confirmed for 1 and 2 by the chiral excitone coupling method applied on their benzoates 9 and 10.