DETECTION OF ESTROGEN BINDING IN HUMAN MAMMARY-CARCINOMA BY IMMUNOFLUORESCENCE - NEW TECHNIQUE UTILIZING BINDING HORMONE IN A POLYMERIZED STATE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 14  (4) , 771-774
Abstract
Detection of neoplastic cells with the ability to bind estrogen was accomplished utilizing the immunofluorescence technique and polymerized estradiol phosphate. Biopsies from 10 patients with the more common varieties of breast cancer were studied and show excellent correlation with independently performed 3H-estradiol receptor assays. Preliminary results show that many mammary carcinomas are composed of heterogenous cell populations which vary in their estrogen binding capacities. To some extent, such variations are dependent on the anatomical location of the malignant cells.

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