An Unusual Case of Phenytoin Intoxication1

Publisher Website
Google Scholar
Abstract
A case of a 10 yr old boy is reported who developed a severe intoxication after the phenytoin treatment was changed from the Ca salt to the free acid. The difference in bioavailability reduced the drug requirement to 55% of the previous dose. The child was also receiving sodium valproate and clonazepam. Serial measurements revealed a significant inverse correlation between the toxic phenytoin serum concentration and the serum level of valproic acid. The measurements of phenytoin as well as of valproic acid showed the value of routine monitoring of anticonvulsant therapy.

This publication has 0 references indexed in Scilit: