Chemotherapy of cervical carcinoma: use of Tc-99m-MAA infusion to predict drug distribution.

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Abstract
Patients (19) with cervical cancer had infusion of 99mTc macroaggregated albumin particles (MAA) via bilateral internal iliac artery catheters to aid in dividing chemotherapeutic dose appropriately between the 2 catheters. Unequal drug distribution was used to minimize extrapelvic complications (local gluteal burns) by reducing the dose to the side with the greatest gluteal perfusion, or to increase the dose to the tumor regions that showed heightened perfusion. Pulmonary uptake, due primarily to arteriovenous shunting in the tumor bed, was seen in all patients. Apparently, bulk reduction of locally advanced cervical carcinoma in patients without prior irradiation may be achieved by intraarterial chemotherapy with tolerable toxicity.

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