Human RNase P: a tRNA-processing enzyme and transcription factor
Open Access
- 5 May 2007
- journal article
- review article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 35 (11) , 3519-3524
- https://doi.org/10.1093/nar/gkm071
Abstract
Ribonuclease P (RNase P) has been hitherto well known as a catalytic ribonucleoprotein that processes the 5′ leader sequence of precursor tRNA. Recent studies, however, reveal a new role for nuclear forms of RNase P in the transcription of tRNA genes by RNA polymerase (pol) III, thus linking transcription with processing in the regulation of tRNA gene expression. However, RNase P is also essential for the transcription of other small noncoding RNA genes, whose precursor transcripts are not recognized as substrates for this holoenzyme. Accordingly, RNase P can act solely as a transcription factor for pol III, a role that seems to be conserved in eukarya.Keywords
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