REGENERATION AND DIFFERENTIATION OF MINCED ANTERIOR TIBIAL MUSCLE EXPLANTS FROM MICE WITH MED MYOPATHY

  • 1 January 1977
    • journal article
    • research article
    • Vol. 36  (3) , 303-309
Abstract
Rapid regeneration of mouse anterior tibial muscle occurred when minced muscle was explanted into the leg of a recipient previously prepared by excision of the corresponding anterior tibial muscle. This technique was used to study regeneration of muscle from mice with a delayed, recessive myopathy, motor endplate disease (MED). There was rapid regeneration of the explanted muscle and functional restoration after 15 wk without signs of MED disease or evidence of the myofiber degeneration which normally occurs after 14 days in homozygous animals. MED disease was not intrinsic in the affected muscles but appeared to be dependent on the general humoral, or possibly neural, environment present in mice with MED disease.

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