Fungicidal activity of cilofungin (LY121019) alone and in combination with anticapsin or other antifungal agents

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Abstract
Cilofungin (LY121019) was shown to have potent fungicidal activity against clinical isolates ofCandida albicans andCandida tropicalis but notCandida parapsilosis. Fungicidal activity was evident against both replicating and non-replicatingCandida albicans and was progressive over the first 12 h of incubation. The combination of cilofungin (LY121019) with anticapsin but not with amphotericin B, ketoconazole or 5-fluorocytosine resulted in synergistic fungicidal activity. This compound warrants further investigation of its safety and efficacy in the treatment ofCandida infections.