The antiseptic properties of further amino derivatives of styryl and anil quinoline

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Abstract
The antiseptic properties of a series of quaternary salts of 2( p -amion anil or styryl) quinoline have already been described (Browning and others, 1926, 1928); the present communication is a continuation of this work. The same methods have been used as before, since with compounds of the present series also the lethal action on bacteria proceeds slowly (Browning, 1922, 1926). Table I shows the inhibitory concentration of the various substances, i. e. , the lowest concentration which suffices to inhibit growth, so that when present in the medium inoculated with the particular organism no definite turbidity to the maked eye develops after 48 hours at 37° C.—subculture the proving sterile or yielding at most a very scanty growth. As has been noted, this concentration appears to yield the most satisfactory indication of the antiseptic effect of a slowly acting bactericidal substance. 2(p- amino anil )-6 acyl amino quinoline derivatives .—Nos. 376, 374, 373, 375, 384, and 379 are analogues of 2( p -amino anil)-6 acetylamino quinoline methochlorid. (No. 45). They are all fairly powerful antiseptics toward both staphylococcus and B. coli and they are little or not at all diminished in their action by serum. The members of the series show no noteworthy progressive differences in antiseptic properties which can be attributed to alternations in the acyl group. The chloracetyl compound (No. 239) is, however, less active in serum, especially toward staphylococcus, and this corresponds with what has been found with the chloracetyl and bromacetyl derivatives of 2( p -dimethylamino anil)-6 amino quinoline ( cf . Nos. 71, 72, and 59).

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