Establishment of a rat hepatoma cell line which has ornithine carbamoyltransferase activity and grows continuously in arginine-deprived medium
- 1 January 1979
- journal article
- research article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 98 (1) , 177-184
- https://doi.org/10.1002/jcp.1040980119
Abstract
The epithelial cell line, H4-II-E derived from Reuber hepatoma H35 has no significant activity of ornithine carbamoyltransferase (OCT, EC 2.1.3.3) and is not able to grow in arginine-deprived medium. A multi-step selection procedure is described which selects from H4-II-E populations, cells with OCT activity which can grow in arginine-deficient, ornithine-supplemented media.This publication has 20 references indexed in Scilit:
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