Inhibitory Effect of a Novel Anticomplementary Agent, K-76COONa, on the Release of Histamine Induced by Zymosan and Compound 48/80

Open Access
Publisher Website
Google Scholar
Abstract
A novel sesquiterpene anticomplementary agent, K-76COONa, if locally applied, was revealed to have an activity to prevent histamine release from rat connective tissue mast cells not only in a zymosan-induced inflammation of the air pouch type (zymosan-air-pouch inflammation) but also in compound 48/80-induced air-pouch inflammation. Moreover, K-76COONa inhibited in vitro histamine release from rat peritoneal mast cells induced by compound 48/80.