ENHANCEMENT OF GLUCOSE-STIMULATED INSULIN SECRETION FROM ISOLATED RAT PANCREATIC ISLETS BY HUMAN INSULIN ANTIBODIES

Abstract
Isolated pancreatic rat islets incubated in vitro were used as a bioassay system for investigating the influence of human insulin antibodies on insulin secretion. Serum samples with different titers of insulin antibodies were obtained from juvenile diabetics after various periods of insulin therapy. The insulin secretion of isolated islets is enhanced by insulin antibodies and positively correlated to the measured antibody titers in serum. [The relationship between a lack of remission in insulin treated diabetes and anti-insulin antibodies is discussed.].

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