ENHANCEMENT OF GLUCOSE-STIMULATED INSULIN SECRETION FROM ISOLATED RAT PANCREATIC ISLETS BY HUMAN INSULIN ANTIBODIES
- 1 September 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 83 (1) , 123-132
- https://doi.org/10.1530/acta.0.0830123
Abstract
Isolated pancreatic rat islets incubated in vitro were used as a bioassay system for investigating the influence of human insulin antibodies on insulin secretion. Serum samples with different titers of insulin antibodies were obtained from juvenile diabetics after various periods of insulin therapy. The insulin secretion of isolated islets is enhanced by insulin antibodies and positively correlated to the measured antibody titers in serum. [The relationship between a lack of remission in insulin treated diabetes and anti-insulin antibodies is discussed.].This publication has 4 references indexed in Scilit:
- Electron microscopy of the pancreatic islets stimulated by insulin antibodyCanadian Journal of Physiology and Pharmacology, 1968
- Insulin Secretion by Isolated Islets in Presence of Glucose, Insulin and Anti-Insulin SerumExperimental Biology and Medicine, 1967
- Production of Autoantibodies to Insulin in Man and RabbitsDiabetes, 1965
- The colorimetric micro-determination of non-esterified fatty acids in plasmaClinica Chimica Acta; International Journal of Clinical Chemistry, 1964