Circulating endothelin-1 levels in obese patients with the metabolic syndrome

1 January 1997

journal article
Published by Georg Thieme Verlag KG in Experimental and Clinical Endocrinology & Diabetes

Vol. 105 (S 02) , 38-40
https://doi.org/10.1055/s-0029-1211794

Abstract

We evaluated venous plasma ET-1 concentrations in 18 never-treated obese men (body mass index 31.0±0.5 kg/m²; age 45.4±4.3 years) showing the whole features of the above syndrome and 12 control men (age 44.1±3.6 years). Circulating ET-1 levels were significantly higher in patients than in controls (p+/Li⁺ counter-transport activity (r=0.504, p=0.033). In conclusion, venous plasma ET-1 levels are elevated in obese men manifesting the whole features of the metabolic syndrome. Due to the biological properties of ET-1, our findings suggest the peptide as a further component of the cluster of cardiovascular risk factors which characterizes this syndrome.

Keywords

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