Mortality From Tuberculous Meningitis Reduced by Steroid Therapy

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Abstract
In this study of 99 tuberculous meningitis patients from Cali, Colombia, treatment with steroids (in conjunction with antituberculous drugs) was more effective in reducing mortality than treatment with antibacterial drugs alone. Results further suggest that low dosages of steroids (1 mg/kg of prednisone daily for 30 days) are equally effective in treating the disease as high dosages (10 mg/kg of prednisone at the start of treatment, gradually reduced over a 30-day period). These results are based on sequential analysis of matched pairs, a statistical method particularly appropriate for clinical trials.

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